The multiplicity of deubiquitinating enzymes (DUBs) encoded by vertebrate genomes is partly attributable to whole genome duplication events that occurred early in chordate evolution. By surveying the literature for the largest family of DUBs (the ubiquitin-specific proteases), extensive functional redundancy for duplicated genes has been confirmed as opposed to singletons. Dramatically conflicting results have been reported for loss of function studies conducted through RNA interference as opposed to inactivating mutations, but the contradictory findings can be reconciled by a recently proposed (...) compensatory mechanism involving nonsense-mediated RNA degradation. Duplicated genes are often inactivated to become pseudogenes, and it is proposed that such is the fate of the USP15 gene of zebrafish, a commonly used model system. As it is reviewed here, these observations have implications not only for the interpretation of model system phenotypes but also for therapeutic interventions designed to target DUBs. (shrink)

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

Research Ethics, Volume 18, Issue 1, Page 24-38, January 2022. Are social science, cross-border research projects, where recruitment and data collection are carried out remotely, required to follow similar ethical and data-sharing procedures as ‘on-the-ground’ studies that use traditional means of recruitment and participant engagement? This article reflects on our experience of dealing with this question when we had to switch to online data collection due to the restrictions posed by the COVID-19 pandemic, such as the inability to travel or (...) work in person with local communities and collaborators. Using social media platforms and online data collection when conducting research brings many advantages, such as being able to communicate remotely but directly with gatekeepers and collaborators, and in reaching potential participants on a global scale. However, neither the guidelines and advice for conducting ethically sound internet-based research, nor the academic literature focussed on building equitable research partnerships between the Global North and the Global South, offer much information regarding the ethical concerns, or address the grey areas, posed by this type of digital and distanced transnational research. In our experience, conducting research remotely made negotiations of access very challenging due to the politics of positionality between Global North and South researchers, lack of clarity on ethical processes and perceptions of gatekeepers who we could not meet in person. We hope the reflections on, and discussion of, our experience encourage deliberation on the present ethical challenges posed by online and social-media-disseminated data collection, particularly in cross-border circumstances. (shrink)

Launched in 1999, at a time of radical change for the publishing industry, Persephone Books has become a successful independent publisher of neglected female authors mainly from the 20th-century inter-war period. Publishing being an industry primarily shaped by the differential distribution of symbolic and economic capital, competing principles of cultural legitimacy within an increasingly commercial climate clarify the position of modern publishing at the intersection of culture and commerce. This article explores how Persephone Books’ understated assertion of publishing’s ‘middle ground’ (...) and commitment to the historically reviled ‘middlebrow’ genre have reconciled the perennial tension between culture and commerce to create a thriving yet unintentional publishing brand. (shrink)

In aging humans, aerobic exercise interventions have been found to be associated with more positive or less negative changes in frontal and temporal brain areas, such as the anterior cingulate cortex (ACC) and hippocampus, relative to no-exercise control conditions. However, individual measures such as gray-matter (GM) probability may afford less reliable and valid conclusions about maintenance or losses in structural brain integrity than a latent construct based on multiple indicators. Here, we established a latent factor of GM structural integrity (...) based on GM probability assessed by voxel-based morphometry, magnetization transfer saturation, and mean diffusivity. Based on this latent factor, we investigated changes in structural brain integrity during a six-month exercise intervention in brain regions previously reported in studies using volumetric approaches. Seventy-five healthy, previously sedentary older adults aged 63–76 years completed an at-home intervention study in either an exercise group (EG;n= 40) or in an active control group (ACG;n= 35). Measures of peak oxygen uptake (VO2peak) taken before and after the intervention revealed a time-by-group interaction, with positive average change in the EG and no reliable mean change in the ACG. Significant group differences in structural brain integrity changes were observed in the right and left ACC, right posterior cingulate cortex (PCC), and left juxtapositional lobule cortex (JLC). In all instances, average changes in the EG did not differ reliably from zero, whereas average changes in the ACG were negative, pointing to maintenance of structural brain integrity in the EG, and to losses in the ACG. Significant individual differences in change were observed for right ACC and left JLC. Following up on these differences, we found that exercising participants with greater fitness gains also showed more positive changes in structural integrity. We discuss the benefits and limitations of a latent-factor approach to changes in structural brain integrity, and conclude that aerobic fitness interventions are likely to contribute to brain maintenance in old age. (shrink)

La 4ème de couverture indique : « Le portrait de Dorian Gray, exhibé dès les premières pages du livre de Wilde auquel il donne son titre, fascine d’emblée le lecteur. La lecture proposée ici souligne que ce portrait, pour ainsi dire jeté en pâture, sert d’écran ou de paravent à un autre portrait encore plus séducteur et inquiétant, en général moins remarqué, celui de la mère morte, représentée en bacchante, qui le hante secrètement. Outre L’imposture de la beauté, ce (...) recueil comprend une étude sur Le Moïse de Michel-Ange de Freud : Un autre Moïse, ou la Force de la loi ; deux lectures consacrées à Nietzsche : Nietzsche et Wagner, Nietzsche et Voltaire (Et pourtant elle tremble!) ; Un battu imbattable, à propos de Larmes de clown, du cinéaste Victor Sjöström ainsi que Angoisse et catharsis, sur The Lady Vanishes, d’Alfred Hitchcock. ». (shrink)

This open-ended anthology is a journey into the very canon that Mary Daly has argued to be patriarchal and demeaning to women. This volume deauthorizes the official canon of Western philosophy and disrupts a related story told by some feminists who claim that Daly’s work is unworthy of re-reading because it contains fatal errors. The editors and contributors attempt to prove that Mary Daly is located in the Western intellectual tradition. Daly may be highly critical of conventional Western epistemological and (...) theological traditions, but she nevertheless appropriates themes “out-of-context” for the building of her own systematic philosophy. The following are just a few of the many themes explored in this volume: • the question of subjectivity understood as an ongoing process of be-coming • the ambiguity of the need for feminists of colonial nations to speak out about violence against women in other parts of the world while that speaking carries with it the stamp of a colonial location • the territoriality of lesbian and women’s space • the theological dimensions of twentieth-century Western philosophy. Contributors are Wanda Warren Berry, Purushottama Bilimoria, Debra Campbell, Molly Dragiewicz, Frances Gray, Amber L. Katherine, AnaLouise Keating, Anne-Marie Korte, María Lugones, Geraldine Moane, Sheilagh A. Mogford, Laurel C. Schneider, Renuka Sharma, and Marja Suhonen. (shrink)

A central problem for the international governance of heritable germline gene editing is that there are important differences in attitudes and values as well as ethical and health care considerations around the world. These differences are reflected in a complicated and diverse regulatory landscape. Several publications have discussed whether reproductive uses would be legally permissible in individual countries and whether clinical applications could emerge in the context of regulatory gaps and gray areas. Systematic comparative studies that explore issues related (...) to the governance of this technology from different national and international perspectives are needed to address the lack of knowledge in this area. In this research report, we contribute to filling this gap by presenting views of stakeholders in the United Kingdom on challenges to the governance of heritable genome editing. We present findings from a multistakeholder study conducted in the United Kingdom between October 2016 and January 2018 and funded by the Wellcome Trust. This research included interviews, literature analysis, and a workshop. We involved leading U.K. scientists, in vitro fertilization clinicians, and representatives from regulatory bodies, patient organizations, and other civil societal organizations, as well as fertility companies. Part one of this article explores stakeholder perceptions of possible global developments in heritable genome editing and associated risks and governance challenges. Part two presents a range of policy options that were generated during the workshop in relation to the challenges discussed in part one. (shrink)

This article addresses the problem of writing the posthuman in educational research. Confronted by our own failures as educational researchers within posthuman and new materialist approaches, it seeks a more radical opening to Lather and St Pierre’s question: ‘If we give up “human” as separate from non-human, how do we exist? … Are we willing to take on this question that is so hard to think but that might enable different lives?’ We do this to enable different lives for the (...) planet in all of its manifestations, including its children of the Anthropocene. We begin with the insistent presence of mud in our deep hanging out in an early learning site and ask: what is mud, what does it do, where can mud lead us in its oozing at Grey Gums Preschool. From these explorations we include a scripted dialogue that was performed at a conference against a background of rolling images of the proliferation of mud’s play with children. We consider this scripted dialogue, and its performance, as data read in relati... (shrink)

Background Many indigenous people have died or been harmed because of inadequately monitored research. Strong regulations in Human Research Ethics (HRE) are required to address these injustices and to ensure that peoples’ participation in health research is safe. Indigenous peoples advocate that research that respects indigenous principles can contribute to addressing their health inequities. This scoping literature review aims to analyze existing peer reviewed and grey literature to explore how indigenous values and principles from countries of Oceania are incorporated into (...) HRE and the governance of research involving human participants. Methods A scoping literature review framework was used for this study. A search for peer reviewed and grey literature from Google, bibliographies, and electronic databases such as SCOPUS, SPRINGER, Medline (Ovid) and JBI Database of Systematic Reviews was conducted, limited to the years 2002–2020. Sixty (60) documents that focused on indigenous knowledge from Oceania region and HRE were included, from which key findings and themes were synthesized. Results Charting the data showed that more than half the eligible documents were peer-reviewed journal articles (54%). Other sources included: International Declarations on Human Research (8%); book chapters (8%); government documents (8%); HRE Guidelines or protocols (13%); news articles (7%) and PhD thesis (2%). The literature was from Australia, Cook Islands, Guam, New Zealand, Fiji, Samoa, Tonga and Vanuatu, some of which focused specifically on HREs in the Pacific Region. Issues emerging from the literature were grouped into five themes (i) indigenous and cultural principles of HRE; (ii) informed consent in indigenous settings in Oceania; (iii) vulnerability and minority status of indigenous populations exploited for research; (iv) research ethics governance for Oceania indigenous peoples; and (v) research ethics committees in Oceania. Respect, relationship building, and trust were priority indigenous HRE principles that encompass the principles of partnership, capacity building, reciprocity, and equality. Relationship building and trust imply the equal distribution of benefits for indigenous population and researchers. Conclusion Indigenous principles of HRE identified were interconnected and interdependent. Recommendations were to incorporate indigenous principles of research in HRE regulations and processes of all countries with indigenous populations. This is especially pertinent for emerging national research committees in LMIC countries, including Fiji and Tonga. Relationship building among researchers and indigenous populations is key to successful research with indigenous populations. HRE principles important for relationship building include respect that is reciprocal among researchers and indigenous people. Elements of the principle of respect highlighted are empathy, collaboration, sharing of benefits, reciprocity, appreciation, empowerment, protection, safety and awareness of culture and languages. Indigenous ontology from the Oceania region involves spirituality, connectedness to land, religious beliefs and a participatory approach to HRE and should be respected in research. An ethical governance mechanism of HRE is one that incorporates indigenous principles and applications for the purpose of maximizing the protection of the dignity and rights of indigenous peoples of Oceania. (shrink)

In our descriptive exploratory qualitative study, we investigated the issue of contract cheating in Iranian higher education contexts. Through our analysis, we provide insights into measures taken in Iran to prevent contract cheating and mitigate its effects. Our study analyses secondary data including scholarly articles, published media, and the country’s current policies. Results showed that more empirical primary data from which to draw definitive conclusions is needed, and as such, developing an evidence-based body of knowledge about the prevalence and characteristics (...) of contract cheating in Iran remains a persistent call to action. Our analysis of scholarly studies (_n_ = 102) and grey literature sources (_n_ = 195) showed an overarching lack of university accountability; students’ motives for engaging in contract cheating; and lack of appropriate legislation were enabling factors. We conclude that Iran lags behind other countries with regards to what is known about contract cheating and how to address it; as such, we conclude with a call to action for increased supports for education; policy and legislation; and scholarship. (shrink)

Environmental change requires individuals and institutions to facilitate adaptive governance. However, facilitating adaptive governance may be difficult because resource users' perceptions of desirable ways of life vary. These perceptions influence preferences related to environmental governance and may stem from the ways individuals subjectively value their work and their connections to their environment. This paper uses a value-based approach to examine individual and institutional preferences for adaptive governance in Carelmapu, Chile. We show that two groups had different value frames rooted in (...) divergent ontologies which influenced their actions related to adaptive governance, creating conflict. (shrink)

Sarah A. Mattice develops a comparative intervention in contemporary metaphilosophy. Drawing on resources from hermeneutics, cognitive linguistics, aesthetics, and Chinese philosophy, she explores how philosophical language is deeply intertwined with the definition and practice of the discipline.

Over the past decade, sexual rumor spreading, slut-shaming, and homophobic labeling have become central examples of bullying among young women. This article examines the role these practices— what adults increasingly call “bullying” and what girls often call “drama”— play in girls’ gendering processes. Through interviews with 54 class and racially diverse late adolescent girls, I explore the content and functions of “sexual drama.” All participants had experiences with this kind of conflict, and nearly a third had been the subject of (...) other girls’ rumors about their own sexual actions and/or orientations. Their accounts indicate that sexual drama offers girls a socially acceptable site for making claims to, and sense of, gendered sexuality in adolescence. While they reproduce inequality through these practices, sexual drama is also a resource for girls—one that is made useful through the institutional constraints of their high schools, which reinforce traditional gender norms and limit sexuality information. (shrink)

This article surveys the latest research on risky-choice framing effects, focusing on the implications for rational decision-making. An influential program of psychological research suggests that people's judgements and decisions depend on the way in which information is presented, or ‘framed’. In a central choice paradigm, decision-makers seem to adopt different preferences, and different attitudes to risk, depending on whether the options specify the number of people who will be saved or the corresponding number who will die. It is standardly assumed (...) that such responses violate a foundational tenet of rational decision-making, known as the principle of description invariance. We discuss recent theoretical and empirical research that challenges the dominant ‘irrationalist’ narrative. These approaches typically pay close attention to how decision-makers represent decision problems (including their interpretation of numerical quantifiers or predicate choice) and they highlight the need for a more robust characterization of the description invariance principle. We conclude by indicating avenues for future research that could bring us closer to a complete—and potentially rationalizing—explanation of framing effects. (shrink)

The Central American country of Guatemala committed itself to democratic values and processes in its election of December, 1985. Guatemala, like most other Central American countries, has been through the dictator-constitution-election revolving door many times. For almsot half a century, Guatemala has been afflicted with coups, general-presidents and dictator-presidents. Again, in 1985, Guatemala created a new constitution with provision for democratic presidential elections monitored and declared "democratic" by a score of other nations. The new president, Vinicio Cerezo, and his Minister (...) of Education, Eduardo Meyer Maldonado, emphasized that the elementary school, the only formal educational institution attended by the majority of Guatemalans, must provide those learning experiences required to develop, to nourish and to sustain democracy in Guatemala. (shrink)

In his recent book, Frame It Again: New Tools for Rational Decision-Making, J. L. Bermúdez argues that it can be rational to evaluate the same thing differently when it is described using alternati...

This paper reviews the location of Responsible Research and Innovation approaches within the access and benefit sharing policy spaces of the Convention on Biological Diversity and Nagoya Protocol. We describe how a range of dialogues on ethical research practices found a home, almost inadvertently, within the ABS policy process. However, more recent RRI dialogues around emerging technologies have not been similarly absorbed into ABS policy, due in part to the original framing of ABS and associated definitional and scope issues. Consideration (...) is given to the challenges posed to these policy processes by the transformative and rapid nature of scientific and technological change today, including the emerging field of synthetic biology. Drawing on experiences from regulating ABS, we emphasize that the integration of RRI into policies for new, emerging, or poorly understood activities such as synthetic biology faces deficiencies such as limits to government capacity, jurisdictional confusion, shortages in funds, and an absence of strategic approaches. We conclude that a coordinated combination of diverse policy processes within the CBD might provide an invaluable space for RRI dialogues on social justice, sustainability, biosafety, and other issues raised by emerging technologies. (shrink)

I use the psychological phenomenon of ‘attribute framing’ as a case study for exploring philosophical conceptions of semantics and the semantics-pragmatics divide. Attribute frames are pairs of sentences that use contradictory expressions to predicate the same property of an individual or object. Despite their equivalence, pairs of attribute frames have been observed to induce systematic variability in hearers’ responses. One explanation of such framing effects appeals to the distinct ‘reference point information’ conveyed by alternative frames. Although this information is taken (...) to be pragmatic, a live debate in the philosophy of language concerns the extent to which pragmatic information can really be held apart from semantics. Therefore, in this article I examine whether – and how – reference point information might be thought to intrude on the semantics of an attribute frame. I describe two ways in which the information might be considered broadly semantic, due to its being directly communicated or conventional. However, I argue that the framing data in fact support a narrower conception of semantics, and a semantics-pragmatics distinction that separates standing sentence meaning from enriched communicated meaning. (shrink)

Collaboration requires agents to coordinate their behavior on the fly, sometimes cooperating to solve a single task together and other times dividing it up into sub‐tasks to work on in parallel. Underlying the human ability to collaborate is theory‐of‐mind (ToM), the ability to infer the hidden mental states that drive others to act. Here, we develop Bayesian Delegation, a decentralized multi‐agent learning mechanism with these abilities. Bayesian Delegation enables agents to rapidly infer the hidden intentions of others by inverse planning. (...) We test Bayesian Delegation in a suite of multi‐agent Markov decision processes inspired by cooking problems. On these tasks, agents with Bayesian Delegation coordinate both their high‐level plans (e.g., what sub‐task they should work on) and their low‐level actions (e.g., avoiding getting in each other's way). When matched with partners that act using the same algorithm, Bayesian Delegation outperforms alternatives. Bayesian Delegation is also a capable ad hoc collaborator and successfully coordinates with other agent types even in the absence of prior experience. Finally, in a behavioral experiment, we show that Bayesian Delegation makes inferences similar to human observers about the intent of others. Together, these results argue for the centrality of ToM for successful decentralized multi‐agent collaboration. (shrink)

Human judgements are affected by the words in which information is presented —or ‘framed’. According to the standard gloss, ‘framing effects’ reveal counter-normative reasoning, unduly affected by positive/negative language. One challenge to this view suggests that number expressions in alternative framing conditions are interpreted as denoting lower-bounded (minimum) quantities. However, it is unclear whether the resulting explanation is a rationalising one. I argue that a number expression should only be interpreted lower-boundedly if this is what it actually means. I survey (...) how number expressions might be assigned lower-bounded meanings, due to their conventional semantics or pragmatic enrichment in context. I argue that deciding between these possibilities requires foundational philosophical input. (shrink)

Traditional notions of civic education often introduce privilege and reproduce Eurocentric notions of citizenship. Proponents of cultural citizenship champion Black cultural knowledge, and critical race pedagogies to help marginalized individuals, including students of color, actualize their agentic selves. This manuscript presents three vignettes to demonstrate how teachers implemented the Black Lives Matter at School’s 13 Guiding Principles to develop Black cultural citizenship with students. Three salient aspects emerged: (1) the need for students to be active contributors in the current movement (...) for Black liberation; (2) a call to support students unlearning and relearning Black history; and (3) instruction that provides opportunities for students to recognize and challenge systems of oppression. (shrink)

Programmed cell death (PCD) or apoptosis is a broadly conserved phenomenon in metazoans, whereby activation of canonical signal pathways induces an ordered dismantling and death of a cell. Paradoxically, the constituent proteins and pathways of PCD (most notably the metacaspase/caspase protease mediated signal pathways) have been demonstrated to retain non‐death functions across all phyla including yeast, nematodes, drosophila, and mammals. The ancient conservation of both death and non‐death functions of PCD proteins raises an interesting evolutionary conundrum: was the primordial intent (...) of these factors to induce cell death or to regulate other cellular adaptations? Here, we propose the hypothesis that apoptotic behavior of PCD proteins evolved or were co‐opted from core non‐death functions. (shrink)

According to some philosophers, a sentence's semantics can fail to constitute a complete propositional content, imposing mere constraints on such a content. Recently, Daniel Harris has begun developing a formal constraint semantics. He claims that the semantic values of sentences constrain what speakers can literally say with them—and what hearers can know about what was said. However, that claim is undermined by his conception of semantics as the study of a psychological module. I argue instead that semantic constraints should be (...) understood as properties of public languages. (shrink)

In his recent book, Frame It Again: New Tools for Rational Decision-Making, J. L. Bermúdez argues that it can be rational to evaluate the same thing differently when it is described using alternati...

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Thicker Jesus: Incarnational Discipleship in a Secular Age by Glen Harold StassenSarah A. NeeleyA Thicker Jesus: Incarnational Discipleship in a Secular Age Glen Harold Stassen Louisville, KY: Westminster John Knox Press, 2012. 280pp. $25.00Glen Stassen’s A Thicker Jesus addresses how one can find a solid ethical identity that provides a framework and path in a rapidly changing world. Stassen begins by considering what those who have stood (...) the test of history, such as Dietrich Bonhoeffer, Karth Barth, Martin Luther King, and Dorothy Day, among others, have in common. He effectively argues that the common thread among these great leaders of resistance is a “thick” exegetical understanding of Jesus Christ that is implemented in daily life through incarnational discipleship. Such a “thick” interpretation of Jesus of Nazareth is rooted in Christian realism rather than Platonic idealism, meaning that incarnational discipleship does not attempt to apply lofty ideals to reality but is deeply involved, following Jesus of Nazareth, in historical struggles. Stassen then argues that this type of ethic can address all of the problems posed to ethics and faith in “a secular age” outlined by Charles Taylor’s book of the same title.Stassen’s framework of incarnational discipleship in a secular age addresses each of Taylor’s seven problems through a tapestry of argumentation that includes history, biblical exegesis, the tradition of Christian ethics, science, and politics. The work is critically engaged with historical figures in Christian ethics and current voices in the field. Stassen contributes a unique voice to the conversation by drawing upon his experiences with science as a trained physicist and with politics through his father’s gubernatorial career. Where many chose critical engagement with the natural and social sciences or with theological and biblical interpretation, Stassen does both. He approaches physics, politics, and economics with theological rigor, drawing upon traditional theological claims and offering his own critique and adaptation. Stassen, in his typical style, draws extensively on the Christian Scriptures. However, he does not simply reference numerous verses but further enhances the complexity of his argumentation through careful exegesis of the Sermon on the Mount, which he is known for, and of the Gospel of Mark.Stassen’s careful examination of the Sermon on the Mount and Mark offers the reader a picture of the particular understanding of Jesus that Stassen argues needs to be “thickly” interpreted; nonetheless, the book does not address [End Page 200] the consequences of other interpretations of Jesus being made “thicker” and the ethical dilemmas of such interpretations. To his credit, Stassen draws on several womanist interpretations of the cross as suffering in solidarity with the oppressed. But what about womanists who claim that any value placed on the suffering of the cross might lead to the excuse that the suffering of the oppressed is, in fact, redemptive suffering? Does a “thicker” interpretation of the cross necessarily address this problem?Overall, Stassen’s contribution to the field cannot be understated. He insists on addressing social problems on their own terms in the language of history, politics, economics, and science; he also rigorously engages theological and biblical ethics when such things have gone out of fashion in social ethics. As an added bonus, Stassen is clear in his call for pluralism and multiple ethical approaches while at the same time offering a rich account rooted in an interpretation of Jesus for Christians.Sarah A. NeeleyIliff School of Theology/University of DenverCopyright © 2013 Society of Christian Ethics... (shrink)

Bermúdez claims that agents think about framed outcomes, not outcomes themselves; and that seemingly incoherent preferences can be rational, once defined over framed outcomes. However, the agents in his examples know that alternative frames describe the same outcome, neutrally understood. This undermines the restriction of their preferences to framed outcomes and, in turn, the argument for rational framing effects.

This article refines a foundational tenet of rational choice theory known as the principle of description invariance. Attempts to apply this principle to human agents with imperfect knowledge have paid insufficient attention to two aspects: first, agents’ epistemic situations, i.e. whether and when they recognize alternative descriptions of an object to be equivalent; and second, the individuation of objects of description, i.e. whether and when objects count as the same or different. An important consequence is that many apparent ‘framing effects’ (...) may not violate the principle of description invariance, and the subjects of these effects may not be irrational. (shrink)

This article brings an anthropology of ethics to bear on a case of forced migration and displacement among Syrian refugee women in Jordan. The case reveals how projects of Islamic self‐making in displacement become “emplacement” processes within the new state‐mediated context. Syrian women in Jordan engage in Islamic self‐making as part of their wider emplacement practices in two primary ways: first, operating more publicly in the material world through Islamically‐inspired actions and rituals than in Syria. Second, utilizing narratives of Islamic (...) histories to establish dignity in conditions of precarity in exile. Using two focus groups in urban Jordan and participant observation in two religion classes in a Syrian refugee camp, this article focuses on these practices of Islamic self‐making that serve an important role in the projects of moral emplacement for Syrian women in the Jordanian context. (shrink)

The debate between Semantic Minimalism and Radical Contextualism is standardly characterized as concerning truth-evaluability—specifically, whether or not sentences require rich contextualization in order to express complete, truth-evaluable contents. In this paper, I examine the notion of truth-evaluability, considering which kinds of mappings it might require from worldly states of affairs to truth-values. At one end of the spectrum, an exhaustive notion would require truth-evaluable contents to map all possible states of affairs to truth-values. At the other end, a liberal notion (...) would require only that truth-evaluable contents map at least one possible state of affairs to at least one truth-value. I show that both Minimalists and Radical Contextualists rely on some intermediate, moderately strict notion of truth-evaluability, falling between these two poles. I consider four ways in which such a notion could be defined. However, I argue that each of these is ultimately implausible, giving us no reason to favour a moderately strict notion of truth-evaluability over the liberal alternative. This suggests that the debate must shift to more moderate ground; rather than concerning the in principle possibility of truth-evaluable contents, it fundamentally hinges on their explanatory value. More generally, paying close attention to the notion of truth-evaluability allows us to tease apart distinct strands in the Minimalism-Contextualism debate, and gain a better appreciation of what is at stake. (shrink)

Framing effects occur when people respond differently to the same information, just because it is conveyed in different words. For example, in the classic ‘Disease Problem’ introduced by Amos Tversky and Daniel Kahneman, people’s choices between alternative interventions depend on whether these are described positively, in terms of the number of people who will be saved, or negatively in terms of the corresponding number who will die. In this paper, I discuss an account of framing effects based on ‘fuzzy-trace theory’. (...) The central claim of this account is that people represent the numbers in framing problems in a ‘gist-like’ way, as ‘some’; and that this creates a categorical contrast between ‘some’ people being saved (or dying) and ‘no’ people being saved (or dying). I argue that fuzzy-trace theory’s gist-like representation, ‘some’, must have the semantics of ‘some and possibly all’, not ‘some but not all’. I show how this commits fuzzy-trace theory to a modest version of a rival ‘lower bounding hypothesis’, according to which lower-bounded interpretations of quantities contribute to framing effects by rendering the alternative descriptions extensionally inequivalent. As a result, fuzzy-trace theory is incoherent as it stands. Making sense of it requires dropping, or refining, the claim that decision-makers perceive alternatively framed options as extensionally equivalent; and the related claim that framing effects are irrational. I end by suggesting that, whereas the modest lower bounding hypothesis is well supported, there is currently less evidence for the core element of the fuzzy trace account. (shrink)

Current philosophical literature is saturated with the debate on biomedical enhancement, where bio-liberals and conservatives alike make compelling arguments for and against the enterprise. However, this literature is yet to consider the impact such enhancement would have on the individual’s actual lived experience. This article seeks to remedy that by situating the bioethics debate within the phenomenology of Maurice Merleau-Ponty, specifically theorising how biomedical enhancement of the physical kind would impact Merleau-Ponty’s notion of the body-subject. The central issue arises when (...) the reciprocal relationship between the physical body and phenomenal world (termed “body/world dynamic”) is shown to be off-balance because of the rapid rate at which human beings continue to “enhance” their environment. In this, we see that the development of the world has outweighed that of the body to the extent that we, as body-subjects, have become maladapted to the place we call home. This article will suggest that we can attempt to resolve this by restoring the balance of the body/world dynamic with “restrictive” enhancement, thereby providing an ethical justification for the pursuit of the enterprise. (shrink)

This study examines the impact of Fair Trade on the sustainability of coffee growing. To examine sustainability we use an ethnographic approach, interviewingproducers and their associated buyers working in Fair Trade organizations in Chiapas Mexico. We focus on social, economic and ecological dimensions of the producers’ and buyers’ experience.

Exploring the Heart Sutra brings an interdisciplinary philosophical approach to this much-loved Buddhist classic. This new translation with commentary situates the sutra in a Chinese context, offering fresh interpretive resources for making sense of this profound work.

Unprecedented levels of access to adolescents' time and attention provide opportunities to convert traditional character and socioemotional competencies interventions into behavioral intervention technologies. However, these new tools must be evaluated rather than assuming previously validated activities will be efficacious when converted to a mobile platform. Thus, we sought to design and provide initial data on the effectiveness of the CharacterMe smartphone app to build self-control and patience, which are built on underlying social-emotional regulation competencies, in a sample of 618 adolescents. (...) We also sought to examine whether framing the app activities as having a transcendent rather than instrumental purpose would increase engagement and change in self-control, patience, and emotion regulation. Finally, we tested the impact of framing activities as building strengths vs. fixing weaknesses. Results highlight the difficulty of translating psychological interventions to behavioral intervention technologies. Overall, the CharacterMe smartphone app was unsuccessful in increasing self-control, patience, or emotion regulation in adolescents, with analyses showing no significant mean changes over time. Framing conditions and user engagement were largely not significant predictors of change in self-control, patience, and emotion regulation. (shrink)